The ER Thioredoxin-Related Transmembrane Protein TMX2 Controls Redox-Mediated Tethering of ER-Mitochondria Contacts (ERMCS)
J. Chen, M. C. Yap, A. Bassot, D. M. Pascual, T. Makio, J. Zimmermann, H. Mast, R. Bhat, S. G. Fleury, Y. Fan, A. Zardini Buzatto, J. Moore, K. Ballanyi, L. Li, M. Overduin, , T. Simmen
This paper identifies TMX2 as a regulator of ER-mitochondria contacts by preventing TOM70 sulfenylation, linking its dysfunction to neurodevelopmental disorders.
bioRxiv · Apr 12, 2024Cell Biology