Author

T. Spielmann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:plant (other)· 6 Research Focus:cell type annotation· 4 Research Focus:host-pathogen & immune response· 4 Assay:proteomics· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:clustering· 2 Research Focus:protein folding & dynamics· 2

Frequent Co-Authors

H. M. Behrens· 5 shared M. Schmitt· 3 shared P. Mesen-Ramirez· 3 shared R. Sabitzki· 3 shared S. Flemming· 3 shared E. Jonscher· 2 shared I. Henshall· 2 shared J. Cronshagen· 2 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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5 shared papersCell Biology

H. M. Behrens

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Identification of domains in Plasmodium falciparum proteins of unknown function using DALI search on Alphafold predictions

H. M. Behrens, T. Spielmann

This study identifies functional domains in uncharacterized Plasmodium falciparum proteins using Alphafold predictions and DALI search, revealing potential roles in RNA processing and transcription.

bioRxiv · Jun 5, 2023 · PreprintCell Biology

Identification of a Rabenosyn-5 like protein and Rab5b in host cell cytosol uptake reveals conservation of endosomal transport in malaria parasites

R. Sabitzki, A.-L. Rossmann, M. Schmitt, S. Flemming, A. Guillen-Samander, H. M. Behrens, E. Jonscher, K. Hoehn, U. Froehlke, T. Spielmann

This study identifies a Rbsn5-like protein and Rab5b in malaria parasites, showing they function in endosomal transport of host cell cytosol, revealing conservation of endosomal mechanisms despite sequence divergence.

bioRxiv · Apr 5, 2023 · PreprintMicrobiology

The Kelch13 compartment is a hub of highly divergent vesicle trafficking proteins in malaria parasites

S. Schmidt, J. S. Wichers-Misterek, H. M. Behrens, J. Birnbaum, I. Henshall, J. Dröge, E. Jonscher, S. Flemming, C. Castro-Pena, P. Mesen-Ramirez, T. Spielmann

The paper identifies novel proteins in the K13 compartment of malaria parasites and shows they are involved in endocytosis and ART resistance, with some showing unique domain structures.

bioRxiv · Dec 15, 2022 · PreprintCell Biology

Gene-by-gene screen of the unknown proteins encoded on P. falciparum chromosome 3

J. Kimmel, M. Schmitt, A. Sinner, P. Jansen, G. Ramon-Zamorano, S. Mainye, C. G. Toenhake, J. S. Wichers, J. Cronshagen, R. Sabitzki, P. Mesen-Ramirez, H. M. Behrens, R. Bartfai, T. Spielmann

This study performs a gene-by-gene screen of non-secretory proteins on P. falciparum chromosome 3 to identify their cellular location, essentiality, and function, revealing key parasite-specific processes.

bioRxiv · Jul 7, 2022 · PreprintCell Biology

Impact of different mutations on Kelch13 protein levels, ART resistance and fitness cost in Plasmodium falciparum parasites

H. M. Behrens, S. Schmidt, D. Peigney, R. Sabitzki, I. Henshall, J. May, O. Maïga-Ascofare, T. Spielmann

This study examines how mutations in K13 and related genes affect ART resistance, protein levels, and fitness cost in Plasmodium falciparum parasites, finding no benefit from double mutations but highlighting the fitness cost of ubp1R3138H.

bioRxiv · May 13, 2022 · PreprintMicrobiology

An unusual trafficking domain in MSRP6 defines a complex needed for Maurer's clefts anchoring and maintenance in P. falciparum infected red blood cells

A. Blancke Soares, J. Staecker, S. Schwald, W. A. M. Hoijmakers, N. G. Metwally, J. Cronshagen, H. Schoeler, S. Flemming, K. Hoehn, U. Froehlke, P. Mesen-Ramirez, B. Bergmann, M. Khosh-Naucke, I. Bruchhaus, R. Bartfai, T. Spielmann

The paper identifies a novel domain in MSRP6 that mediates Maurer's clefts anchoring and maintenance in P. falciparum, but shows these functions are dispensable for PfEMP1 transport and cytoadherence.

bioRxiv · Dec 3, 2021 · PreprintMicrobiology

Identification of novel inner membrane complex and apical annuli proteins of the malaria parasite Plasmodium falciparum

J. S. Wichers, J. Wunderlich, D. Heincke, S. Pazicky, J. Strauss, M. Schmitt, J. Kimmel, L. Wilcke, S. Scharf, H. von Thien, P.-C. Burda, T. Spielmann, C. Loew, M. Filarsky, A. Bachmann, T. W. Gilberger

This study identifies new IMC and apical annuli proteins in Plasmodium falciparum using BioID proteomics and validates their localization.

bioRxiv · Feb 3, 2021Cell Biology