M. Schmitt

The origin of intestinal cancer in the context of inflammation

The paper shows that secretory cell lineages, not stem cells, can trigger tumor formation in the context of inflammation and Western-style diets, which are major colon cancer risk factors.

Proteomic profiling identifies Serpin B9 as mediator of resistance to CAR T-cell and bispecific antibody treatment in B-cell lymphoma

Identification of a Rabenosyn-5 like protein and Rab5b in host cell cytosol uptake reveals conservation of endosomal transport in malaria parasites

This study identifies a Rbsn5-like protein and Rab5b in malaria parasites, showing they function in endosomal transport of host cell cytosol, revealing conservation of endosomal mechanisms despite sequence divergence.

Gene-by-gene screen of the unknown proteins encoded on P. falciparum chromosome 3

This study performs a gene-by-gene screen of non-secretory proteins on P. falciparum chromosome 3 to identify their cellular location, essentiality, and function, revealing key parasite-specific processes.

A polyyne toxin produced by an antagonistic bacterium blinds and lyses a green microalga

This study identifies a polyyne toxin produced by Pseudomonas protegens that blinds and lyses Chlamydomonas reinhardtii by targeting its eyespot, alongside orfamide A, to disrupt phototaxis.

Identification of novel inner membrane complex and apical annuli proteins of the malaria parasite Plasmodium falciparum

This study identifies new IMC and apical annuli proteins in Plasmodium falciparum using BioID proteomics and validates their localization.

Analysis of Amino Acid Variants in Malignant Melanoma Cells Resistant to BRAF inhibition

The paper uses proteogenomics to analyze amino acid variants in BRAF inhibitor-resistant melanoma cells, identifying PTM changes and predicting effective therapies.