S. Flemming

Identification of a Rabenosyn-5 like protein and Rab5b in host cell cytosol uptake reveals conservation of endosomal transport in malaria parasites

This study identifies a Rbsn5-like protein and Rab5b in malaria parasites, showing they function in endosomal transport of host cell cytosol, revealing conservation of endosomal mechanisms despite sequence divergence.

The Kelch13 compartment is a hub of highly divergent vesicle trafficking proteins in malaria parasites

The paper identifies novel proteins in the K13 compartment of malaria parasites and shows they are involved in endocytosis and ART resistance, with some showing unique domain structures.

Soluble VE-cadherin disrupts endothelial barrier function via VE-PTP/RhoA signalling

This study shows that soluble VE-cadherin fragments disrupt endothelial barrier function by interfering with VE-PTP/RhoA signaling in both in vitro and in vivo models.

Tyrosine kinase inhibitors trigger lysosomal damage-associated cell lysis to activate the NLRP3 inflammasome

A small molecule screen identifies tyrosine kinase inhibitors that cause lysosomal damage, leading to cell lysis and NLRP3 inflammasome activation via K+ efflux.

Versatile patterns in the actin cortex of motile cells: Self-organized pulses can coexist with macropinocytic ring-shaped waves

The paper identifies a mechanism allowing different actin patterns to coexist in motile cells using bifurcation theory and live-cell imaging.

An unusual trafficking domain in MSRP6 defines a complex needed for Maurer's clefts anchoring and maintenance in P. falciparum infected red blood cells

The paper identifies a novel domain in MSRP6 that mediates Maurer's clefts anchoring and maintenance in P. falciparum, but shows these functions are dispensable for PfEMP1 transport and cytoadherence.