Modulation of SARS-CoV-2 spike binding to ACE2 throughconformational selection
P. Saha, I. Fernanadez, F. Sumbul, C. Valotteau, D. Kostrz, A. Meola, E. Baquero, A. Sharma, J. R. Portman, F. Stransky, T. Boudier, P. Guardado Calvo, C. Gosse, T. Strick, F. A. Rey, F. Rico
This study uses single-molecule techniques to show that SARS-CoV-2 spike protein RBD dynamics modulate ACE2 binding through conformational selection without affecting unbinding.
bioRxiv · Mar 15, 2024Biophysics