T. Boudier

Modulation of SARS-CoV-2 spike binding to ACE2 throughconformational selection

This study uses single-molecule techniques to show that SARS-CoV-2 spike protein RBD dynamics modulate ACE2 binding through conformational selection without affecting unbinding.

Coupled mechanical mapping and interference contrast microscopy reveal viscoelastic and adhesion hallmarks of monocytes differentiation into macrophages

This study uses mechanical and adhesion imaging to show that macrophages become stiffer and more adhesive than monocytes during differentiation.

Apical Actin-myosin Network Regulates the Tight Junction of Polarized Madin-Darby Canine Kidney Cells

This study shows that the apical actin network regulates tight junction morphology and permeability through in-plane tension in MDCK cells.

Chromosomes distribute randomly to, but not within, human neutrophil nuclear lobes

The paper shows human chromosomes randomly distribute to neutrophil nuclear lobes but maintain non-random radial organization within lobes, revealing new insights into chromosome territory dynamics.

Macrophages provide a transient muscle stem cell niche via NAMPT secretion

The paper identifies macrophages as a transient niche for muscle stem cells through NAMPT secretion, which activates CCR5 on stem cells to drive muscle regeneration.

An Erg driven transcriptional program controls B-lymphopoiesis

This study identifies Erg as a critical transcription factor initiating B-lymphopoiesis by regulating gene networks essential for B-cell development and V(D)J recombination.

A novel generic dictionary-based denoising method for improving noisy and densely packed nuclei segmentation in 3D time-lapse fluorescence microscopy images

The paper introduces a denoising method for improving nuclei segmentation in 3D time-lapse fluorescence microscopy images, achieving high recall on benchmark datasets.