F. Rico

Modulation of SARS-CoV-2 spike binding to ACE2 throughconformational selection

This study uses single-molecule techniques to show that SARS-CoV-2 spike protein RBD dynamics modulate ACE2 binding through conformational selection without affecting unbinding.

MechanoProDB: A Web Based Database for Exploring the Mechanical Properties of Proteins

MechanoProDB is a web-based database that curates and provides access to experimental and computational data on protein mechanical properties, enabling exploration of unfolding forces and conformational stability.

Reliable, standardized measurements for cell mechanical properties

The paper develops a standardized protocol for measuring mechanical properties of cancer cells using AFM, achieving consistent results across multiple laboratories.

Coupled mechanical mapping and interference contrast microscopy reveal viscoelastic and adhesion hallmarks of monocytes differentiation into macrophages

This study uses mechanical and adhesion imaging to show that macrophages become stiffer and more adhesive than monocytes during differentiation.

Combining DNA scaffolds and acoustic force spectroscopy to characterize individual protein bonds

The paper combines DNA scaffolds and acoustic force spectroscopy to measure single-molecule protein bond rupture under force, showing agreement with standard techniques.

BIN1 regulates actin-membrane interactions during IRSp53-dependent filopodia formation

This study shows BIN1 is required for filopodia formation by bundling actin and recruiting dynamin and ezrin, dependent on IRSp53 and membrane curvature.

Human septins in cells organize as octamer-based filaments mediating actin-membrane anchoring

This study shows that human septins form octamer-based filaments that mediate actin-membrane anchoring, as demonstrated through various imaging and biophysical techniques.

Viscoelastic properties of suspended cells measured with shear flow deformation cytometry

This paper introduces a microfluidic method to measure viscoelastic properties of suspended cells using shear flow deformation cytometry and demonstrates cell cycle-dependent rheological behavior.

Monitoring Unfolding of Titin I27 single- and bi-Domain with High-Pressure NMR Spectroscopy.

This study uses high-pressure NMR to analyze the unfolding of titin I27 domains, confirming the AG β-sheet as a critical structural element and revealing differences from previous MD simulation findings.