Author

T. Toptan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 4 Approach:experimental assay· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

S. Ciesek· 4 shared D. Bojkova· 2 shared M. Widera· 2 shared A. Berger· 1 shared A. Hiemisch· 1 shared A. L. Siemund· 1 shared A. L. Vera-Guapi· 1 shared A. Pfeiffer· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersMicrobiology

S. Ciesek

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

MicrobiologybioRxivPreprintFeb 23, 2023

Machine learning on large scale perturbation screens for SARS-CoV-2 host factors identifies β-catenin/CBP inhibitor PRI-724 as a potent antiviral

M. A. Kelch, A. L. Vera-Guapi, T. Beder…·R. König

This paper uses machine learning on perturbation screens to identify PRI-724 as a potent antiviral targeting β-catenin/CBP, effective against multiple coronaviruses and influenza.

DOI 10.1101/2023.02.23.529833

humanbulk RNA-seq

𝕏 PostBluesky

Pharmacology & ToxicologyiSciencePeer-reviewedFeb 1, 2023

Identification of novel antiviral drug candidates using an optimized SARS-CoV-2 phenotypic screening platform

D. Bojkova, P. Reus, L. Panosch…·J. Cinatl

This study develops a phenotypic screening platform using caspase 3/7 activity to identify antiviral compounds against SARS-CoV-2, including novel candidates and combinations.

DOI 10.1016/j.isci.2023.105944

humanbulk RNA-seq

𝕏 PostBluesky

MicrobiologybioRxivPreprintApr 27, 2021

Generation of a Sleeping Beauty transposon-based cellular system for rapid and sensitive identification of SARS-CoV-2 host dependency and restriction factors

M. Widera, A. Wilhelm, T. Toptan…·R. Marschalek

This paper develops a Sleeping Beauty transposon-based cell system for rapid and sensitive detection of SARS-CoV-2 infection and screening of host factors.

DOI 10.1101/2021.04.27.441606

humanbulk RNA-seq

𝕏 PostBluesky

MicrobiologybioRxivApr 20, 2020

Optimized qRT-PCR approach for the detection of intra- and extracellular SARS-CoV-2 RNAs

T. Toptan, S. Hoehl, S. Westhaus…·M. Widera

This study presents an optimized qRT-PCR method for detecting SARS-CoV-2 RNA using a low-cost SYBR green approach, showing improved detection limits and simplicity compared to multi-step assays.

DOI 10.3390/ijms21124396

virusbulk RNA-seq

𝕏 PostBluesky