Author

M. Suarez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Animal Behavior & Cognition· 1 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Assay:behavioral assay· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

J. Guatelli· 3 shared P. W. Ramirez· 3 shared C. Stoneham· 2 shared R. Singh· 2 shared X. Jia· 2 shared A. A. Angerstein· 1 shared A. Debray· 1 shared A. J. Eisch· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersMicrobiology

J. Guatelli

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Behavioral pattern separation and cognitive flexibility are enhanced in a mouse model of increased lateral entorhinal cortex-dentate gyrus circuit activity

S. Yun, I. Soler, F. H. Tran, H. A. Haas, R. Shi, G. L. Bancroft, M. Suarez, C. R. de Santis, R. P. Raynolds, A. J. Eisch

This study shows that increasing lateral entorhinal cortex-dentate gyrus circuit activity in mice improves behavioral pattern separation and cognitive flexibility, along with increased neurogenesis.

bioRxiv · Jan 26, 2023 · PreprintAnimal Behavior & Cognition

Nef enhances HIV-1 replication and infectivity independently of SERINC3 and SERINC5 in CEM T cells

P. W. Ramirez, T. Vollbrecht, F. M. Acosta, M. Suarez, A. A. Angerstein, J. Wallace, R. M. O'Connell, J. Guatelli

This study shows that HIV-1 Nef enhances replication and infectivity in CEM T cells without relying on SERINC3 or SERINC5 antagonism.

bioRxiv · Jul 15, 2020Microbiology

Structural Basis of CD4 Downregulation by HIV-1 Nef

Y. Kwon, R. Kaake, I. Echeverria, M. Suarez, C. Stoneham, P. W. Ramirez, J. Kress, R. Singh, A. Sali, N. J. Krogan, J. Guatelli, X. Jia

This paper presents a high-resolution crystal structure of HIV-1 Nef interacting with AP2, revealing how Nef sequesters CD4 for degradation and identifying a dual-function pocket crucial for both MHC recruitment and CD4 binding.

bioRxiv · Apr 21, 2020Biochemistry

A conserved acidic cluster motif in SERINC5 confers resistance to antagonism by HIV-1 Nef

C. Stoneham, P. W. Ramirez, R. Singh, M. Suarez, A. Debray, C. Lim, X. Jia, Y. Xiong, J. Guatelli

This paper identifies an acidic cluster motif in SERINC5 that mediates resistance to HIV-1 Nef antagonism, showing its importance in Nef sensitivity without affecting intrinsic antiviral activity.

bioRxiv · Mar 27, 2019Microbiology