BiophysicsbioRxivPreprint
Heat hypersensitivity of ryanodine receptor type 1 mutants implicated in malignant hyperthermia
K. Oyama, V. Zeeb, T. Yamazawa…·M. Suzuki
The paper shows that heat hypersensitive RyR1 mutants cause heat-induced Ca2+ release, contributing to malignant hyperthermia through a positive feedback loop.
DOI 10.1101/2020.10.29.351452