Cancer BiologybioRxiv
Physical confinement promotes mesenchymal trans-differentiation of invading transformed cells in vivo
T. Z. Coarasa, J. Fadul, M. Ahmed, J. Rosenblatt
The paper shows that mechanical confinement drives mesenchymal trans-differentiation of invasive KRasV12-transformed cells in zebrafish, contributing to metastasis.
DOI 10.1016/j.isci.2022.105330