BiophysicsbioRxivPreprint
Targeting the Plasmodium falciparum UCHL3 ubiquitin hydrolase using chemically constrained peptides
H. R. King, M. Bycroft, T.-B. Nguyen…·K. Artavanis-Tsakonas
This study identifies chemically constrained peptides that inhibit PfUCHL3, a critical deubiquitinating enzyme in Plasmodium falciparum, by blocking substrate binding rather than active site interaction.
DOI 10.1101/2024.01.11.575158