Regulation of gene transcription by thyroid hormone receptor β agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH)
X. G. Luong, S. K. Stevens, A. Jekle, T.-I. Lin, K. Gupta, D. Misner, S. Chanda, S. Mukherjee, C. Williams, A. Stoycheva, L. M. Blatt, L. N. Beigelman, J. A. Symons, P. Raboisson, D. McGowan, , J. Deval
This study compares the efficacy of three THRβ agonists in modulating gene expression related to cholesterol and fatty acid metabolism in human and rat models.
bioRxiv · Sep 25, 2020Pharmacology & Toxicology