This study shows that type I IFN promotes the maturation of inflammatory monocytes into pathogenic FasL+MCs during H5N1 infection, contributing to disease severity.

bioRxiv · Jan 10, 2022 · PreprintImmunology

A combined EM and proteomic analysis places HIV-1 Vpu at the crossroads of retromer and ESCRT complexes: PTPN23 is a Vpu-cofactor

C. A. Stoneham, S. Langer, P. De Jesus, J. Wozniak, J. Lapek, T. Deerinck, A. Thor, L. Pache, S. Chanda, D. Gonzalez, M. Ellisman, J. Guatelli

This paper identifies PTPN23 as a Vpu-cofactor and maps Vpu's interactions with retromer and ESCRT complexes using EM and proteomics.

bioRxiv · Feb 22, 2021Microbiology

ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model

K. Vandyck, R. Abdelnabi, K. Gupta, D. Jochmans, A. Jekle, J. Deval, D. Misner, D. Bardiot, C. S. Foo, C. Liu, S. Ren, L. Beigelman, L. M. Blatt, S. Boland, L. Vangeel, , J. Neyts

This study evaluates ALG-097111, a selective SARS-CoV-2 3CLpro inhibitor, showing potent in vitro activity and significant in vivo antiviral effects in Syrian hamsters.

bioRxiv · Feb 14, 2021Microbiology

The Autism Risk Factor CHD8 Is a Chromatin Activator and Functionally Dependent on the ERK-MAPK Pathway Effector ELK1

B. Haddad Derafshi, T. Danko, S. Chanda, P. Batista, U. Litzenburger, Q. Y. Lee, Y. H. Ng, A. Sebin, H. Y. Chang, T. C. Sudhof, M. Wernig

This study identifies CHD8 as a chromatin activator in human neurons that depends on the ERK-MAPK pathway effector ELK1 for its function.

bioRxiv · Nov 10, 2020Cell Biology

Functional Landscape of SARS-CoV-2 Cellular Restriction

L. Martin-Sancho, M. K. Lewinski, L. Pache, C. Stoneham, X. YIN, D. Pratt, C. Churas, S. B. Rosenthal, S. Liu, P. D. De Jesus, A. M. O'Neill, A. P. Gounder, C. Nguyen, Y. Pu, A. L. Oom, , S. Chanda

This study identifies key interferon stimulated genes (ISGs) that restrict SARS-CoV-2 infection by inhibiting viral entry, RNA synthesis, and release.

bioRxiv · Sep 29, 2020Microbiology

Regulation of gene transcription by thyroid hormone receptor β agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH)

X. G. Luong, S. K. Stevens, A. Jekle, T.-I. Lin, K. Gupta, D. Misner, S. Chanda, S. Mukherjee, C. Williams, A. Stoycheva, L. M. Blatt, L. N. Beigelman, J. A. Symons, P. Raboisson, D. McGowan, , J. Deval

This study compares the efficacy of three THRβ agonists in modulating gene expression related to cholesterol and fatty acid metabolism in human and rat models.

bioRxiv · Sep 25, 2020Pharmacology & Toxicology

A JAK/STAT-Mediated Inflammatory Signaling Cascade Drives Oncogenesis In AF10-Rearranged AML

B. Chen, A. Deshpande, K. O. Barbosa, M. Kleppe, X. Lei, N. Yeddula, A. Rosa Campos, R. Wechsler-Reya, A. Bagchi, S. Meshinchi, C. J. Eaves, I. Jeremias, T. Haferlach, D. Frank, Z. Ronai, , A. Deshpande

This study identifies JAK1 as a therapeutic target in AF10-rearranged AML by showing its role in JAK/STAT-mediated inflammatory signaling and oncogenesis.

bioRxiv · Aug 31, 2020Cancer Biology

A Large-scale Drug Repositioning Survey for SARS-CoV-2 Antivirals

L. Riva, S. Yuan, X. Yin, L. Martin-Sancho, N. Matsunaga, S. Burgstaller, L. Pache, P. De Jesus, M. V. Hull, M. Chang, J. F. W. Chan, J. Cao, V. Kwok-Man Poon, K. Herbert, T.-T. Nguyen, , S. Chanda

This study identifies 30 known drugs that inhibit SARS-CoV-2 replication, with six showing effective concentrations likely to be therapeutic in patients.

bioRxiv · Apr 16, 2020 · PreprintMicrobiology