Author

D. McGowan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:rat· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Jekle· 1 shared A. Stoycheva· 1 shared C. Williams· 1 shared D. Misner· 1 shared H. Suga· 1 shared J. A. Symons· 1 shared J. Abid· 1 shared J. Deval· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperPharmacology & Toxicology

A. Jekle

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2 papers

Recent·Most cited

Regulation of gene transcription by thyroid hormone receptor β agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH)

X. G. Luong, S. K. Stevens, A. Jekle, T.-I. Lin, K. Gupta, D. Misner, S. Chanda, S. Mukherjee, C. Williams, A. Stoycheva, L. M. Blatt, L. N. Beigelman, J. A. Symons, P. Raboisson, D. McGowan, , J. Deval

This study compares the efficacy of three THRβ agonists in modulating gene expression related to cholesterol and fatty acid metabolism in human and rat models.

bioRxiv · Sep 25, 2020Pharmacology & Toxicology

Human trans-editing enzyme displays tRNA acceptor stem specificity and relaxed amino acid selectivity

O. Vargas-Rodriguez, M. Bakhtina, D. McGowan, J. Abid, Y. Goto, H. Suga, K. Musier-Forsyth

This study examines how human ProXp-ala recognizes tRNA acceptor stem elements and amino acids, showing specificity changes compared to bacterial enzymes.

bioRxiv · Sep 11, 2020Biochemistry