T.-W. Li

KDM5A/B promotes HIV-1 latency and KDM5 inhibitors promote HIV-1 lytic reactivation

This study shows that KDM5A/B promote HIV-1 latency and their inhibition with JQKD82, combined with AZD5582, reactivates HIV-1 and induces cell death.

SARS-CoV-2 Nsp14 activates NF-κB signaling and induces IL-8 upregulation

This study shows that SARS-CoV-2 Nsp14 activates NF-κB signaling and increases IL-8 expression, which is confirmed in infected cells and lung tissue from COVID-19 patients.