Cell BiologybioRxivPreprint
Tankyrase interacts with the allosteric site of glucokinase and inhibits its glucose-sensing function in the beta cell
N.-W. Chi, T. Eisemann, T.-Y. J. Yeh…·O. Osborn
This study identifies tankyrase (TNKS) as a physiological inhibitor of glucokinase (GCK) in pancreatic beta cells by trapping it in an inactive conformation.
DOI 10.1101/2021.08.08.454510