NeurosciencebioRxivPreprint
Cav3.1 is a leucine sensor in POMC neurons mediating appetite suppression and weight loss
Anthony H. K. Tsang, Nicholas Heeley, Constanza Alcaino…·Clémence Blouet
2 citations
Author
Tamana Darwish
University of Cambridge
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
Biology Disciplines
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2017-2024 · peak 1/yrCo-Author Collaboration Network
10 top collaborators · 37 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship4 papers
Recent·Most cited
- NeuroscienceMolecular MetabolismPeer-reviewed
Nutrient sensing in the nucleus od the solitary tract mediates non-aversive suppression of feeding via inhibition of AgRP neurons.
Anthony H. K. Tsang, Danaé Nuzzaci, Tamana Darwish…·Clémence Blouet
The paper identifies a neural circuit in the nucleus of the solitary tract (NTS) that suppresses feeding by inhibiting AgRP neurons through leucine sensing and leptin-receptor-expressing neurons.
41 citations - NeuroscienceMolecular MetabolismPeer-reviewed
Rapid sensing of L-leucine by human and murine hypothalamic neurons: neurochemical and mechanistic insights
Nicholas Heeley, Peter Kirwan, Tamana Darwish…·Clémence Blouet
This study identifies novel Ca2+ signaling mechanisms by which hypothalamic neurons in mice and humans rapidly respond to L-leucine, showing both activation and inhibition of specific neuron types.
- NeuroscienceeLifePeer-reviewed
mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice
Luke K. Burke, Tamana Darwish, Althea R Cavanaugh…·Clémence Blouet
This study shows mTORC1 in AGRP neurons integrates food-related cues to control iBAT thermogenesis in mice, linking energy availability to adaptive energy expenditure.
60 citations