the OCCAMs consortium

This study identifies AP-1 as a key transcription factor mediating ERBB2-driven mesenchymal-like properties in oesophageal adenocarcinoma through integrated phosphoproteomics, open chromatin profiling, and transcriptome analysis.

The paper identifies enhancer RNAs in oesophageal adenocarcinoma using RNA-seq and open chromatin maps, revealing new deregulated pathways and their clinical relevance.

The paper shows that ERBB2 inhibition in OAC cells leads to chromatin remodelling and rewiring of gene regulatory networks, enabling resistance through metabolic shifts and transcriptional regulators.

The paper identifies a cell cycle gene expression signature in Oesophageal Adenocarcinoma (OAC) and shows KLF5's repurposing to regulate cell cycle genes during progression from Barrett's oesophagus to OAC.