Developmentally regulated PERK activity renders dendritic cells insensitive to subtilase cytotoxin-induced integrated stress response
P. Pierre, A. Mendes, J. P. Gigan, C. Rodriguez Rodrigues, S. A. Choteau, D. Sanseau, D. Barros, C. Almeida, V. Camosseto, L. Chasson, A. W. Paton, J. C. Paton, R. J. Argüello, A.-M. Lennon-Dumenil, E. Gatti
The paper shows dendritic cells have high eIF2 phosphorylation due to PERK activation, but this does not lead to chronic ISR or translation arrest, allowing them to adapt to stress.
bioRxiv · Apr 27, 2020 · PreprintImmunology