B. Samad

Critical role of CD206+ macrophages in promoting a cDC1-NK-CD8 T cell anti-tumor immune axis

This study shows that CD206+ macrophages support an anti-tumor network involving cDC1, NK cells, and CD8 T cells, and their depletion impairs tumor control in mice and correlates with poor survival in humans.

Multimodal delineation of a layer of effector function among exhausted CD8 T cells in tumors

The paper identifies a potent effector state among exhausted CD8 T cells in tumors using multimodal CITE-Seq, showing enhanced cytokine production and tumor-killing ability.

Tumor cell heterogeneity drives spatial organization of the intratumoral immune response in squamous cell skin carcinoma

This study shows that tumor cell heterogeneity influences the spatial organization of immune responses in squamous cell skin carcinoma, affecting immunotherapy outcomes.

Cyclone: an accessible pipeline to analyze, evaluate and optimize multiparametric cytometry data

Cyclone is a pipeline for analyzing, evaluating, and optimizing multiparametric cytometry data, demonstrating effectiveness across multiple cytometry technologies and biological contexts.

Dynamic CD8+ T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted by metastasis

The paper examines CD8+ T cell responses in human lymph nodes during cancer immunotherapy and finds that metastasis disrupts these responses.

Myeloid mechano-metabolic programming restricts anti-tumor immunity

This study shows that fibrotic tumor microenvironments impair anti-tumor immunity through myeloid cell-driven metabolic changes that hinder CD8+ T cell function.

Spatiotemporal co-dependency between macrophages and exhausted CD8+ T cells in cancer

This study investigates the interaction between macrophages and exhausted CD8+ T cells in the tumor microenvironment, showing they form a feedback loop that promotes tumor survival.

Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer

This study characterizes monocyte-to-macrophage differentiation in kidney cancer using scRNA-seq, linking immune phenotypes to T cell function and patient outcomes.

Active Surveillance Characterizes Human Intratumoral T Cell Exhaustion

The paper studies T cell exhaustion in human tumors using live-biopsy and two-photon microscopy, finding variable T cell speed and a link between motility and exhaustion state.

A Pan-Cancer Census of Dominant Tumor Immune Archetypes

The paper identifies dominant immune system archetypes across 364 tumors from 12 cancer types using flow cytometry and transcriptomic data, linking them to tumor biology classifications.

SCENITH: A flow cytometry based method to functionally profile energy metabolism with single cell resolution

SCENITH functionally profiles energy metabolism at single-cell resolution using flow cytometry, revealing variable metabolic profiles in tumor myeloid cells not linked to lineage or activation phenotype.