Dietary restriction of isoleucine increases healthspan and lifespan of genetically heterogeneous mice
C. L. Green, M. E. Trautman, R. Babygirija, R. Jain, K. Chaiyakul, H. H. Pak, A. Bleicher, G. Novak, M. M. Sonsalla, C.-Y. Yeh, M. F. Calubag, T. T. Liu, V. Flores, S. Newman, W. A. Ricke, , D. Lamming
This study shows that reducing dietary isoleucine improves metabolic health, reduces frailty, and extends lifespan in genetically diverse mice.
bioRxiv · Oct 6, 2022Physiology