D. Lamming

Dietary isoleucine content defines the metabolic and molecular response to a Western diet

This study shows that reducing dietary isoleucine improves metabolic health in mice on a Western diet, with distinct molecular responses across sexes and strains.

Individual dietary amino acid restrictions induce distinct metabolic and chromatin states

The paper investigates how dietary restriction of specific essential amino acids affects metabolism and chromatin states in mice, finding distinct effects for methionine, leucine, and isoleucine.

Late-life isoleucine restriction promotes physiological and molecular signatures of healthy aging

This study shows that reducing amino acids or isoleucine in the diet of aged mice improves metabolic health, reduces frailty, and slows aging markers.

Dietary restriction of isoleucine increases healthspan and lifespan of genetically heterogeneous mice

This study shows that reducing dietary isoleucine improves metabolic health, reduces frailty, and extends lifespan in genetically diverse mice.

FGF21 has a sex-specific role in calorie-restriction-induced beiging of white adipose tissue in mice

This study investigates the role of FGF21 in calorie-restricted diet-induced metabolic changes in mice, finding it dispensable for most effects but sex-specific in adipose tissue beiging.

Regulation of metabolic health by dietary histidine in mice

This study shows that reducing dietary histidine improves metabolic health and body composition in mice and explains BMI differences in humans.

Contrasting recruitment of skin-associated adipose depots during cold challenge of mouse and human

This study compares the function and regulation of skin-associated adipose depots in mice and humans during cold exposure, finding distinct thermoregulatory strategies.