V. K. Rao

This study shows that altering CMPK2 expression disrupts macrophage mitochondrial function and dysregulates basal inflammation.

This study shows that inhibiting triglyceride synthesis in TB granulomas reduces bacterial load and inflammation by targeting DGAT1.

This study identifies GIMAP5 as a lymphocyte-specific regulator of senescence, showing that rapamycin can restore naive T cell levels in GIMAP5-deficient patients.

The paper identifies how modern Mtb strains use the type I IFN pathway to manipulate host immune responses through enhanced phagosomal acidification and cholesterol metabolism.

Hem1 loss-of-function mutations cause congenital immunodysregulation by disrupting WAVE2 and mTORC2 complexes, leading to immunodeficiency and immune hyperresponsiveness.