A Nanoparticle RIG-I Agonist for Cancer Immunotherapy
L. Wang-Bishop, M. Wehbe, L. E. Pastora, J. Yang, K. M. Garland, K. W. Becker, C. S. Carson, K. N. Gibson-Corley, D. Ulkoski, V. Krishnamurthy, O. Fedorova, A. Richmond, A. M. Pyle, J. T. Wilson
This paper develops SLR-LNPs, a nanoparticle-based RIG-I agonist, showing enhanced tumor immunogenicity and improved response to immune checkpoint inhibitors in mouse cancer models.
bioRxiv · Apr 25, 2023 · PreprintBioengineering