Author

A. M. Pyle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Immunology· 2 Bioengineering· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 4 Research Focus:host-pathogen & immune response· 2 Assay:long-read sequencing· 2 Assay:bulk RNA-seq· 1 Organism:C. elegans· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

O. Fedorova· 3 shared A. Iwasaki· 2 shared G. Mahadeshwar· 2 shared A. Richmond· 1 shared B. Israelow· 1 shared B. L. Menasche· 1 shared C. B. F. Vogels· 1 shared C. B. Wilen· 1 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersBioengineering

O. Fedorova

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

MRT-ModSeq - Rapid detection of RNA modifications with MarathonRT

R. d. C. Araujo Tavares, G. Mahadeshwar, H. Wan, A. M. Pyle

The paper introduces MRT-ModSeq, a method for rapid detection of multiple RNA modifications using MarathonRT, and demonstrates its ability to identify various modifications across RNA transcripts.

bioRxiv · May 25, 2023Biochemistry

A Nanoparticle RIG-I Agonist for Cancer Immunotherapy

L. Wang-Bishop, M. Wehbe, L. E. Pastora, J. Yang, K. M. Garland, K. W. Becker, C. S. Carson, K. N. Gibson-Corley, D. Ulkoski, V. Krishnamurthy, O. Fedorova, A. Richmond, A. M. Pyle, J. T. Wilson

This paper develops SLR-LNPs, a nanoparticle-based RIG-I agonist, showing enhanced tumor immunogenicity and improved response to immune checkpoint inhibitors in mouse cancer models.

bioRxiv · Apr 25, 2023 · PreprintBioengineering

A compact regulatory RNA element in mouse Hsp70 mRNA

W. Wang, F. Liu, M. V. Ugalde, A. M. Pyle

The paper identifies a compact RNA structure in mouse Hsp70 mRNA that may regulate cap-independent translation during heat shock.

bioRxiv · Feb 22, 2023Biochemistry

A stem-loop RNA RIG-I agonist confers prophylactic and therapeutic protection against acute and chronic SARS-CoV-2 infection in mice

T. Mao, B. Israelow, C. Lucas, C. B. F. Vogels, O. Fedorova, M. I. Breban, B. L. Menasche, H. Dong, M. Linehan, Yale SARS-CoV-2 Genome Surveillance Initiative, C. B. Wilen, M. L. Landry, N. D. Grubaugh, A. M. Pyle, A. Iwasaki

This study shows that SLR14, a RIG-I agonist, prevents and treats SARS-CoV-2 infection in mice, including chronic cases and variants, through IFN-I responses.

bioRxiv · Jun 16, 2021Immunology

Structural insights into the role of Dicer-related helicase 3 in RNAi in Caenorhabditis elegans.

K. Li, J. Zheng, M. Wirawan, T. M. Nguyen, O. Fedorova, P. Griffin, A. M. Pyle, D. Luo

This study determines the crystal structures of DRH-3 domains bound to RNA, revealing structural features that explain its role in RNAi and evolutionary divergence from Dicer-like helicases.

bioRxiv · Mar 14, 2021 · PreprintBiochemistry

The global and local distribution of RNA structure throughout the SARS-CoV-2 genome

R. d. C. A. Tavares, G. Mahadeshwar, A. M. Pyle

This study analyzes the RNA structure distribution in the SARS-CoV-2 genome, finding it has higher stable folding propensity than HCV and identifies structural density in accessory and structural ORFs.

Journal of Virology · Feb 10, 2021Peer-reviewedBiophysics

A minimal RNA ligand for potent RIG-I activation in living mice

M. M. Linehan, T. H. Dickey, E. S. Molinari, M. E. Fitzgerald, O. Potapova, A. Iwasaki, A. M. Pyle

This study develops synthetic RNA ligands that activate RIG-I in mice, inducing interferon responses and specific gene expression, and shows their potential as therapeutic tools.

bioRxiv · Aug 19, 2017Immunology