Cell BiologybioRxiv
Enhanced mitochondrial G-quadruplex formation impedes replication fork progression leading to mtDNA loss in human cells
M. Doimo, S. Abrahamsson, V. L'Hote…·S. Wanrooij
The paper shows that mitochondrial DNA replication stalling increases G-quadruplex formation, which blocks replication forks and leads to mtDNA loss in human cells.
DOI 10.1093/nar/gkad535