Defective Desmosomal Adhesion Causes Arrhythmogenic Cardiomyopathy by involving an Integrin-αVβ6/TGF-β Signaling Cascade
C. Schinner, H. Franz, A. Zimmermann, M.-T. Wanuske, F. Geier, P. Pelczar, V. Lorenz, L. Xu, C. Stuedle, P. I. Maly, S. Kauferstein, B. M. Beckmann, G. M. Kuster, V. Spindler
This study shows that defective desmosomal adhesion causes arrhythmogenic cardiomyopathy through an integrin-αVβ6/TGF-β signaling cascade, leading to fibrosis and arrhythmias.
bioRxiv · Sep 2, 2021Cell Biology