A. Zimmermann

ATR inhibition augments the efficacy of lurbinectedin in small cell lung cancer

This study shows that combining ATR inhibition with lurbinectedin improves efficacy in SCLC, particularly in MYC-driven non-neuroendocrine tumors.

Desmosomal cell cohesion and epidermal differentiation are modulated by dolichol phosphate mannosyltransferase 1 (DPM1) through SERPINB5-dependent mechanisms

This study shows that DPM1 modulates desmosomal cohesion and epidermal differentiation via SERPINB5-dependent regulation of desmoplakin phosphorylation.

Multi-omics reveals principles of gene regulation and pervasive non-productive transcription in the human cytomegalovirus genome

The paper uses multi-omics data to model HCMV gene regulation, identifying over 2,600 viral transcripts and explaining protein expression kinetics through transcription start sites and RNA stability.

Defective Desmosomal Adhesion Causes Arrhythmogenic Cardiomyopathy by involving an Integrin-αVβ6/TGF-β Signaling Cascade

This study shows that defective desmosomal adhesion causes arrhythmogenic cardiomyopathy through an integrin-αVβ6/TGF-β signaling cascade, leading to fibrosis and arrhythmias.

Arabidopsis mTERF9 protein promotes chloroplast ribosomal assembly and translation by establishing ribonucleoprotein interactions in vivo.

This study identifies Arabidopsis mTERF9 as a protein that promotes chloroplast ribosomal assembly and translation by interacting with ribosomal components and RNA.

Translational profiling of macrophages infected with Leishmania donovani identifies mTOR- and eIF4A-sensitive immune-related transcripts

This study identifies mTOR- and eIF4A-sensitive immune-related transcripts in Leishmania donovani-infected macrophages, showing their role in modulating mRNA metabolism and immune responses.