Targeting of Cdc42 GTPase in regulatory T cells unleashes anti-tumor T cell immunity
K. W. Kalim, J.-Q. Yang, M. Wunderlich, V. Modur, P. Nguyen, Y. Li, T. Wen, A. Kuenzi, R. Verma, Q. R. Lu, A. G. Jegga, Y. Zheng, F. Guo
This study shows that targeting Cdc42 in regulatory T cells promotes anti-tumor immunity without causing autoimmunity by inducing Treg plasticity and altering pH through carbonic anhydrase I.
bioRxiv · Sep 23, 2021 · PreprintImmunology