BioengineeringbioRxiv
Altered DNA repair pathway engagement by engineered CRISPR-Cas9 nucleases
V. P. Chauhan, P. A. Sharp, R. Langer
This study designs a CRISPR-Cas9 variant that preferentially uses homology-directed repair over nonhomologous end-joining, enabling precise editing and reducing indels in both dividing and non-dividing cells.
DOI 10.1073/pnas.2300605120