P. A. Sharp

Wild edible yams from Madagascar: New insights into nutritional composition support their use for food security and conservation

This study analyzes the nutrient composition of nine wild edible yam species from Madagascar and compares them to cultivated D. alata, showing comparable starch and lipid levels but highlighting higher β-carotene, calcium, and iron in some species.

Altered DNA repair pathway engagement by engineered CRISPR-Cas9 nucleases

This study designs a CRISPR-Cas9 variant that preferentially uses homology-directed repair over nonhomologous end-joining, enabling precise editing and reducing indels in both dividing and non-dividing cells.

A two-gene strategy increases the iron and zinc concentration of wheat flour and improves mineral bioaccesibility for human nutrition.

This paper demonstrates a transgenic strategy in wheat that increases iron and zinc concentrations in flour and improves their bioaccessibility for human nutrition.

CDK13 Mutations Drive Melanoma via Accumulation of Prematurely Terminated Transcripts

This study identifies CDK13 mutations in melanoma, showing they lead to accumulation of truncated transcripts and poor survival, with a mechanism involving impaired ZC3H14 phosphorylation and PAXT complex recruitment.

Networks of enhancers and microRNAs drive variation in cell states

The paper identifies enhancers and microRNAs as drivers of cell state variation in embryonic stem cells, showing how they form feedback loops to generate new cell states.