Cooperative binding of TCR and CD4 to pMHC enhances TCR sensitivity
M. N. Rushdi, V. Pan, K. Li, H.-K. Choi, S. Choi, J. Hong, F. Griffitts, P. Agnihotri, R. A. Mariuzza, Y. Ke, C. Zhu
The paper shows CD4 enhances TCR sensitivity by forming trimolecular bonds with pMHC, which are stabilized by force and proximity.
bioRxiv · Nov 22, 2021 · PreprintImmunology