Y. Ke

Genome-wide CRISPR screen identifies AC9 as a key regulator of ER calcium homeostasis involved in neuronal differentiation.

The paper identifies AC9 as a key regulator of ER calcium homeostasis during neuronal differentiation using CRISPR screening and functional analysis.

High-Throughput DNA melt measurements enable improved models of DNA folding thermodynamics

This paper introduces a high-throughput method to measure DNA melting and develops models to improve DNA folding thermodynamics predictions.

DNA Nanostructure-Guided Assembly of Proteins into Programmable Shapes

This paper describes a method using DNA origami to guide the assembly of protein-DNA conjugates into programmable nanostructures with controlled stoichiometry and geometry.

On Casein Kinase-2 (CK2) deregulation in NSCLC: an enzyme subunit-centered approach

This study investigates CK2 subunit deregulation in NSCLC using multiomics data and IHC, finding that CSNK2A1 and CSNK2B upregulation correlates with poor prognosis and tumor progression.

Mechanism of DNA origami folding elucidated by mesoscopic simulations

This paper develops a mesoscopic simulation model to study DNA origami folding, revealing hierarchical processes and kinetic differences between small and large structures.

MORC proteins regulate transcription factor binding by mediating chromatin compaction in active chromatin regions

The paper investigates RdDM-independent functions of MORC proteins, showing they compact chromatin and repress gene expression by reducing TF accessibility, especially under stress.

Mechano-Cas12a Assisted Tension Sensor (MCATS) for Massively Amplified Cell Traction Force Measurements

MCATS detects cell-generated forces using CRISPR-Cas12a, showing drug effects on platelet forces and identifying platelet dysfunction after cardiopulmonary bypass.

Long-term passaging of replication competent pseudo-typed SARS-CoV-2 reveals the antiviral breadth of monoclonal and bispecific antibody cocktails

This study evaluates the antiviral breadth of monoclonal and bispecific antibody cocktails against SARS-CoV-2 variants using a replication competent VSV-SARS-CoV-2 model, showing resistance to mutation in two cocktails.

A new species of Nanhsiungchelys (Testudines: Cryptodira: Nanhsiungchelyidae) from the Upper Cretaceous of Nanxiong Basin, China, and the role of anterolateral processes on the carapace in drag reduction

The paper describes a new turtle species and investigates the function of carapace anterolateral processes using computational fluid dynamics.

Haplotype resolved DNA methylome of African cassava genome

This study presents a haplotype-resolved DNA methylome of the African cassava genome using long-read sequencing and chromosomal conformation capture techniques.

Efficient Neutralization of SARS-CoV-2 Omicron and Other VOCs by a Broad Spectrum Antibody 8G3

This study evaluates the neutralization efficacy of antibodies against SARS-CoV-2 Omicron and other variants, finding that antibody 8G3 maintains broad neutralizing activity while EUA antibodies lose effectiveness.

Comprehensive Evaluation of ACE2-Fc Combination with Neutralization Antibody on Broad Protection against SARS-CoV-2 and Its Variants

This study evaluates ACE2-Fc combined with neutralizing antibodies against SARS-CoV-2 variants, showing enhanced neutralization and resistance to escape mutations.

Rare Monoclonal Antibody Discovery Based on Indirect Competitive Screening of Single Hapten-specific Rabbit Antibody Secreting Cell

This paper introduces a method to discover rare rabbit monoclonal antibodies against small molecules using an indirect competitive screening approach, resulting in a highly stable antibody with exceptional halophilic properties.

Cooperative binding of TCR and CD4 to pMHC enhances TCR sensitivity

The paper shows CD4 enhances TCR sensitivity by forming trimolecular bonds with pMHC, which are stabilized by force and proximity.

Broad ultra-potent neutralization of SARS-CoV-2 variants by monoclonal antibodies specific to the tip of RBD

This paper identifies a monoclonal antibody, 2G1, that neutralizes all SARS-CoV-2 variants with high potency and describes its mechanism of action and therapeutic efficacy in animal models.

Targeting of Protein Kinase CK2 Elicits Antiviral Activity on Bovine Coronavirus Infection

This study shows that CIGB-325, an anti-CK2 peptide, inhibits bovine coronavirus infection by reducing viral protein accumulation and cytopathic effects.

Targeting of Protein Kinase CK2 in Acute Myeloid Leukemia Cells Using the Clinical-Grade Synthetic-Peptide CIGB-300

This study investigates the anti-proliferative and proapoptotic effects of the CK2 inhibitor CIGB-300 on AML cells and identifies its molecular targets.