Cell BiologybioRxivPreprint
Hyperactive end joining repair mediates resistance to DNA damaging therapy in p53-deficient cells
R. J. Kumar, H. X. Chao, V. R. Roberts…·G. P. Gupta
The paper identifies hyperactive end joining repair in p53-deficient cells as a mechanism of resistance to DNA-damaging therapies and shows that combined inhibition of DNA-PK and Pol theta restores sensitivity.
DOI 10.1101/2020.04.01.021253