J. E. Purvis

This study identifies cell cycle plasticity as a mechanism for fractional resistance to palbociclib in ER+/HER2- breast tumor cells using single-cell imaging and computational analysis.

Mre11 facilitates cGAS activation by displacing it from nucleosome sequestration, promoting ZBP1-dependent necroptosis and suppressing tumor growth.

This study maps the molecular architecture of cell cycle arrest by analyzing 49 effectors, identifying stress-specific arrest states and mechanisms, and showing convergence onto a senescent state with a G1-like signature.

The paper uses single-cell transcriptomics to analyze healthy adult human small intestine and colon epithelium, identifying lineage markers, regional differences, and functional variations across anatomical regions.

This study identifies cyclin F as a regulator of p130/RBL2 degradation via SCF, showing its role in cell cycle control and potential implications in cancer.

The paper uses single-cell imaging and manifold learning to reveal alternative cell cycle paths and mechanisms of exit and re-entry in human cells.

The paper identifies hyperactive end joining repair in p53-deficient cells as a mechanism of resistance to DNA-damaging therapies and shows that combined inhibition of DNA-PK and Pol theta restores sensitivity.

This study shows autophagy regulates p16INK4a localization and degradation via lysosomal pathways, affecting cellular senescence and disease.

The paper introduces PIP-FUCCI, a new reporter system for precise detection of S phase onset, revealing that APCCdh1 inactivation is not strictly required for S phase entry.