Author

R. J. Kumar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Assay:DNA methylation· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

D. A. Simpson· 2 shared G. P. Gupta· 2 shared J. E. Purvis· 2 shared A. M. Goddard· 1 shared A. R. Sullivan· 1 shared A. Y. Ho· 1 shared A.-S. Wozny· 1 shared C. E. Foster· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersCell Biology

D. A. Simpson

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Author profile →

2 papers

Recent·Most cited

Mre11 liberates cGAS from nucleosome sequestration during tumorigenesis

M.-G. Cho, R. J. Kumar, C.-C. Lin, J. A. Boyer, J. A. Shahir, K. Fagan-Solis, D. A. Simpson, C. Fan, C. E. Foster, A. M. Goddard, Q. Wang, Y. Wang, A. Y. Ho, P. Liu, c. J. perou, , G. P. Gupta

Mre11 facilitates cGAS activation by displacing it from nucleosome sequestration, promoting ZBP1-dependent necroptosis and suppressing tumor growth.

bioRxiv · Dec 9, 2022Cell Biology

Hyperactive end joining repair mediates resistance to DNA damaging therapy in p53-deficient cells

R. J. Kumar, H. X. Chao, V. R. Roberts, A. R. Sullivan, S. J. Shah, D. A. Simpson, W. Feng, A.-S. Wozny, S. Kumar, J. E. Purvis, G. P. Gupta

The paper identifies hyperactive end joining repair in p53-deficient cells as a mechanism of resistance to DNA-damaging therapies and shows that combined inhibition of DNA-PK and Pol theta restores sensitivity.

bioRxiv · Apr 1, 2020 · PreprintCell Biology