Author

D. A. Simpson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Ecology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Assay:DNA methylation· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

G. P. Gupta· 2 shared J. E. Purvis· 2 shared R. J. Kumar· 2 shared A. A. Bergen· 1 shared A. C. Mashau· 1 shared A. M. Goddard· 1 shared A. M. Muasya· 1 shared A. R. Sullivan· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCell Biology

G. P. Gupta

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Global analysis of Poales diversification - parallel evolution in space and time into open and closed habitats

T. L. Elliott, D. Spalink, I. Larridon, A. R. Zuntini, M. Escudero, J. Hackel, R. L. Barrett, S. Martin-Bravo, J. I. Marquez-Corro, C. G. Mendoza, A. C. Mashau, K. J. Romero-Soler, D. A. Zhigila, B. Gehrke, C. O. Andrino, , A. M. Muasya

This study analyzes Poales diversification, showing parallel evolution into open and closed habitats across time and space, with distinct patterns in major families.

bioRxiv · Sep 14, 2023Ecology

Mre11 liberates cGAS from nucleosome sequestration during tumorigenesis

M.-G. Cho, R. J. Kumar, C.-C. Lin, J. A. Boyer, J. A. Shahir, K. Fagan-Solis, D. A. Simpson, C. Fan, C. E. Foster, A. M. Goddard, Q. Wang, Y. Wang, A. Y. Ho, P. Liu, c. J. perou, , G. P. Gupta

Mre11 facilitates cGAS activation by displacing it from nucleosome sequestration, promoting ZBP1-dependent necroptosis and suppressing tumor growth.

bioRxiv · Dec 9, 2022Cell Biology

Zinc supplementation induced transcriptional changes in primary human retinal pigment epithelium: a single cell RNA sequencing study to understand age-related macular degeneration

E. Emri, O. Cappa, C. Kelly, E. Kortvely, J. P. SanGiovanni, B. McKay, A. A. Bergen, D. A. Simpson, I. Lengyel

This study uses single-cell RNA sequencing to examine how zinc supplementation affects the transcriptome of human retinal pigment epithelial cells, identifying genes and pathways involved in AMD-related processes.

bioRxiv · Sep 1, 2022Cell Biology

Hyperactive end joining repair mediates resistance to DNA damaging therapy in p53-deficient cells

R. J. Kumar, H. X. Chao, V. R. Roberts, A. R. Sullivan, S. J. Shah, D. A. Simpson, W. Feng, A.-S. Wozny, S. Kumar, J. E. Purvis, G. P. Gupta

The paper identifies hyperactive end joining repair in p53-deficient cells as a mechanism of resistance to DNA-damaging therapies and shows that combined inhibition of DNA-PK and Pol theta restores sensitivity.

bioRxiv · Apr 1, 2020 · PreprintCell Biology