Drug reformulation for a neglected disease. The NANOHAT project to develop a safer more effective sleeping sickness drug.
L. Sanderson, M. da Silva, G. N. Sekhar, R. C. Brown, H. Burrell-Saward, M. Fidanboylu, B. Liu, L. A. Dailey, C. A. Dreiss, C. Lorenz, M. Christie, S. Persaud, V. Yardley, S. L. Croft, M. Valero, S. A. Thomas
This paper develops an intravenous pentamidine formulation using Pluronic micelles to enhance CNS exposure for stage 2 HAT treatment, finding no major neurotoxicity but limited BBB penetration enhancement.
bioRxiv · Apr 18, 2019Pharmacology & Toxicology