Pharmacology & ToxicologybioRxiv
Drug reformulation for a neglected disease. The NANOHAT project to develop a safer more effective sleeping sickness drug.
L. Sanderson, M. da Silva, G. N. Sekhar…·S. A. Thomas
This paper develops an intravenous pentamidine formulation using Pluronic micelles to enhance CNS exposure for stage 2 HAT treatment, finding no major neurotoxicity but limited BBB penetration enhancement.
DOI 10.1371/journal.pntd.0009276