Author

S. A. Thomas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Ecology· 1 Immunology· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 5 Approach:experimental assay· 5 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Assay:metabolomics· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

S. P. Brown· 5 shared J. B. Rattray· 4 shared J. Gurney· 4 shared Y. Wang· 2 shared A. A. Shah· 1 shared A. El-Zayat· 1 shared A. M. Rule· 1 shared A. S. Flecker· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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5 shared papersMicrobiology

S. P. Brown

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Air pollution drives macrophage senescence through a phagolysosome-15-lipoxygenase pathway

S. A. Thomas, H. M. Yong, A. M. Rule, N. Gour, S. Lajoie

This study shows urban particulate matter induces macrophage senescence through a phagolysosome-15-lipoxygenase pathway, independent of inflammasome or scavenger receptor pathways.

ImmunoHorizons · Apr 16, 2024Peer-reviewedImmunology

The las and rhl Quorum Sensing Systems in Pseudomonas aeruginosa Form a Multi-Signal Reciprocal Network Which Can Tune Reactivity to Variations in Physical and Social Environments

S. A. Thomas, A. El-Zayat, J. Gurney, J. B. Rattray, S. P. Brown

The paper shows that the las and rhl quorum sensing systems in Pseudomonas aeruginosa interact reciprocally and cooperatively, enhancing their responsiveness to environmental changes.

bioRxiv · Feb 23, 2023 · PreprintMicrobiology

The dynamic response of quorum-sensing to density is robust to signal supplementation and signal synthase knockouts

J. B. Rattray, P. Kramer, J. Gurney, S. A. Thomas, S. P. Brown

This study investigates how quorum-sensing (QS) in Pseudomonas aeruginosa responds to genetic and signal perturbations, showing robustness in density-dependent gene expression despite signal supplementation or synthase knockouts.

bioRxiv · Sep 12, 2022 · PreprintMicrobiology

Bacterial quorum sensing allows graded and bimodal cellular responses to variations in population density

J. B. Rattray, S. A. Thomas, Y. Wang, E. Molotkova, J. Gurney, J. Varga, S. P. Brown

This study shows Pseudomonas aeruginosa uses quorum sensing to produce graded and bimodal responses to population density changes, without a clear threshold for gene expression activation.

bioRxiv · Dec 15, 2021 · PreprintMicrobiology

Objective method reveals minimum time required to quantify net cost of transport across slow to fast walking speeds

B. Adeyeri, S. A. Thomas, C. J. Arellano

The paper develops an objective method to determine the minimum time needed for steady-rate metabolism during walking, finding that 2-4 minutes of data is sufficient for accurate net cost of transport curves.

bioRxiv · Sep 21, 2021 · PreprintPhysiology

Pseudomonas aeruginosa reaches collective decisions via transient segregation of quorum sensing activities across cells

P. Jayakumar, S. A. Thomas, S. P. Brown, R. Kuemmerli

This study shows Pseudomonas aeruginosa cells transiently segregate into low and high receptor expressers to regulate quorum sensing, providing a bet-hedging strategy.

bioRxiv · Mar 22, 2021 · PreprintMicrobiology

Temperature-dependence of metabolic rate in tropical and temperate aquatic insects: support for the Climate Variability Hypothesis in mayflies but not stoneflies.

A. A. Shah, H. A. Woods, J. C. Havird, E. C. Encalada, A. S. Flecker, W. C. Funk, J. M. Guayasamin, B. K. Kondratieff, N. L. Poff, S. A. Thomas, K. R. Zamudio, C. K. Ghalambor

This study examines the thermal sensitivity of metabolic rates in tropical and temperate aquatic insects, finding greater sensitivity in tropical mayflies but not stoneflies.

bioRxiv · Dec 25, 2019Ecology

Drug reformulation for a neglected disease. The NANOHAT project to develop a safer more effective sleeping sickness drug.

L. Sanderson, M. da Silva, G. N. Sekhar, R. C. Brown, H. Burrell-Saward, M. Fidanboylu, B. Liu, L. A. Dailey, C. A. Dreiss, C. Lorenz, M. Christie, S. Persaud, V. Yardley, S. L. Croft, M. Valero, S. A. Thomas

This paper develops an intravenous pentamidine formulation using Pluronic micelles to enhance CNS exposure for stage 2 HAT treatment, finding no major neurotoxicity but limited BBB penetration enhancement.

bioRxiv · Apr 18, 2019Pharmacology & Toxicology

In silico bacteria evolve robust cooperation via complex quorum-sensing strategies

Y. Wang, J. B. Rattray, S. A. Thomas, J. Gurney, S. P. Brown

The paper uses agent-based simulations to study how environmental factors shape the evolution of quorum-sensing strategies in bacteria, revealing how genetic constraints influence cooperation and resilience against cheaters.

bioRxiv · Apr 3, 2019Microbiology