C. Lorenz

WhaleSonic: Recordings of cetacean vocal behaviour with hydrophone arrays in Northern Norway

WhaleSonic provides a raw acoustic dataset of cetacean vocalizations in Northern Norway, supporting multichannel algorithms for source separation and communication analysis.

Familiarity of an environment prevents song suppression in isolated zebra finches

This study finds that social isolation in a familiar environment does not suppress singing in zebra finches, unlike isolation in an unfamiliar environment.

Understanding the binding mechanisms of Alzheimer risk factor TREM2 in lipid bilayer using multi-scale molecular dynamics simulations

This paper uses multi-scale molecular dynamics simulations to study the TREM2/DAP12 transmembrane domain complex formation and its role in Alzheimer's disease.

Phospholipid tail asymmetry allows cellular adaptation to anoxic environments

The paper shows that anoxic cells use asymmetric phospholipid acyl-tail length to maintain membrane fluidity, replacing unsaturated species that require oxygen.

Keratin filament mechanics and energy dissipation are determined by metal-like plasticity

The paper compares the mechanical behavior of keratin and vimentin filaments using optical tweezers and a computational model, finding they dissipate energy differently.

Extracting extended vocal units from two neighborhoods in the embedding plane

The paper introduces a semi-supervised method to segment and cluster vocalizations by identifying two density-based regions in low-dimensional embeddings, achieving lower false positive error rates.

Multiscale mechanics and temporal evolution of vimentin intermediate filament networks

This study investigates the mechanics and temporal evolution of vimentin intermediate filament networks using multiscale approaches and finds that hydrophobic and electrostatic forces influence network stability and reorganization.

Post-Translational Modifications Soften Vimentin Intermediate Filaments

This study investigates how post-translational modifications, specifically phosphorylation and 14-3-3 binding, affect the mechanical properties of vimentin intermediate filaments.

Tuning Intermediate Filament Mechanics by Variation of pH and Ion Charges

This study investigates how pH and ion concentration affect the mechanical properties of vimentin intermediate filaments using optical trapping and simulations.

Vimentin Intermediate Filaments Stabilize Dynamic Microtubules by Direct Interactions

This study shows vimentin intermediate filaments stabilize microtubules by direct interactions, providing insights into cytoskeletal dynamics and a method to estimate tubulin dimer binding energy.

In vitro model for resistance in oncogene-dependent tumors at the limit of radiological detectability

The paper develops an in vitro model to study resistance mechanisms in oncogene-dependent tumors and shows that combining drugs targeting multiple resistance pathways can inhibit resistant and drug-tolerant cell growth.

Lateral Subunit Coupling Determines Intermediate Filament Mechanics

This study compares the mechanical properties of keratin and vimentin filaments, showing vimentin's mechanics depend on ionic strength and involve strong lateral subunit coupling.

Drug reformulation for a neglected disease. The NANOHAT project to develop a safer more effective sleeping sickness drug.

This paper develops an intravenous pentamidine formulation using Pluronic micelles to enhance CNS exposure for stage 2 HAT treatment, finding no major neurotoxicity but limited BBB penetration enhancement.