The role of sigma-1 receptor in organization of endoplasmic reticulum signaling microdomains
V. Zhemkov, J. Ditlev, W.-R. Lee, J. Liou, M. K. Rosen, I. Bezprozvanny
This study investigates how the sigma-1 receptor (S1R) forms cholesterol-enriched microdomains in the ER and modulates signaling through changes in membrane thickness and cholesterol concentration.
bioRxiv · Dec 4, 2020Cell Biology