R. Fiolka

The Vps13-like protein BLTP2 is pro-survival and regulates phosphatidylethanolamine levels in the plasma membrane to maintain its fluidity and function

This study identifies BLTP2 as a pro-survival protein that regulates phosphatidylethanolamine levels in the plasma membrane to maintain its fluidity and function, linking it to cancer aggressiveness.

In vivo profiling of site-specific human cancer cell states in zebrafish

The paper uses zebrafish xenografts and computer vision to study how Ewing Sarcoma cell morphology changes in different sites and under EWSR1-FLI1 expression variations.

A systematic and quantitative comparison of lattice and Gaussian light-sheets

This study compares lattice and Gaussian light-sheets quantitatively, finding they are similar in thickness, confocal parameter, and propagation length.

Extended depth of focus multiphoton microscopy via incoherent pulse splitting

The paper introduces a phase mask to extend depth of focus in multiphoton microscopy with minimal lateral resolution loss and demonstrates its effectiveness in imaging fixed brain samples.

Direct Arp2/3-vinculin binding is essential for cell spreading, but only on compliant substrates and in 3D

The paper investigates the role of actin-binding proteins in cell spreading on 2D and 3D substrates, finding that Arp2/3-vinculin binding is critical for 3D spreading but not 2D.

A unified role for membrane-cortex detachment during cell protrusion initiation

The paper shows that membrane-cortex detachment is essential for initiating both pressure-based and actin-based protrusions, challenging the Brownian ratchet model and unifying protrusion regulation.

Light-sheet microscopy with isotropic, sub-micron resolution and solvent-independent large-scale imaging

This paper introduces ctASLM, a light-sheet microscopy technique with sub-micron isotropic resolution and large-scale imaging, enabling automated cell and subcellular feature detection in cleared tissues.

An image-based assay to quantify changes in proliferation and viability upon drug treatment in 3D microenvironments

This paper introduces an image-based assay to measure drug effects on cell proliferation and viability in 3D microenvironments, showing 3D single cells are as effective as spheroids for drug screening.