ImmunologyJCI InsightPeer-reviewed
Treatment of anti-myeloperoxidase glomerulonephritis using recombinant deoxyribonuclease I is enhanced by adeno-associated virus gene therapy
Anne Cao Le, Virginie Oudin, Jonathan Dick…·Kim Maree O’Sullivan
This study shows that DNase I treatment reduces ecDNA-driven inflammation in MPO-ANCA GN, and gene therapy enhances its therapeutic effect by extending its half-life.
3 citations