Author

W. D. Andrews

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Cell Biology· 1

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Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Approach:statistical model· 1

Frequent Co-Authors

B. Bilanges· 1 shared C.-Y. Chung· 1 shared E. Topley· 1 shared G. E. Valdebenito· 1 shared G. Szabadkai· 1 shared J. H. Ahn· 1 shared J. Tan· 1 shared K. Singh· 1 shared

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2020-2020 · peak 1/yr

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B. Bilanges

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1 paper

Recent·Most cited

Cell BiologybioRxivPreprintJun 18, 2020

Constitutive activation of the PI3K-Akt-mTORC1 pathway sustains the m.3243A>G mtDNA mutation

C.-Y. Chung, K. Singh, V. N. Kotiadis…·M. R. Duchen

The paper shows that the m.3243A>G mtDNA mutation activates the PI3K-Akt-mTORC1 pathway, which can be inhibited to reduce mutant mtDNA load and improve cellular function.

DOI 10.1101/2020.06.18.159103

humanbulk RNA-seq

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