Author

W. Downing

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 2 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1 Organism:virus· 1

Frequent Co-Authors

G. Downey· 2 shared G. Zhang· 2 shared H. Liu· 2 shared K. Aviszus· 2 shared L. Reynoso· 2 shared P. Marrack· 2 shared P. Wei· 2 shared Q. Zhang· 2 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

G. Downey

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2 papers

Recent·Most cited

501Y.V2 and 501Y.V3 variants of SARS-CoV-2 lose binding to Bamlanivimab in vitro

H. Liu, P. Wei, Q. Zhang, Z. Chen, K. Aviszus, W. Downing, S. Peterson, L. Reynoso, G. Downey, S. Frankel, J. Kappler, P. Marrack, G. Zhang

The paper shows that the 501Y.V2 and 501Y.V3 SARS-CoV-2 variants have mutations that reduce binding to the antibody Bamlanivimab.

bioRxiv · Feb 16, 2021Biochemistry

The basis of a more contagious 501Y.V1 variant of SARS-COV-2

G. Zhang, H. Liu, Q. Zhang, P. Wei, Z. Chen, K. Aviszus, J. Yang, W. Downing, S. Peterson, C. Jiang, B. Liang, L. Reynoso, G. Downey, S. Frankel, J. Kapper, P. Marrack

This paper investigates the increased transmissibility of the SARS-CoV-2 501Y.V1 variant due to the N501Y mutation in the Spike protein's RBD and its impact on ACE2 binding and vaccine efficacy.

bioRxiv · Feb 2, 2021Biochemistry