Author

J. Kappler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Immunology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 2 Assay:proteomics· 2 Organism:virus· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

P. Marrack· 4 shared G. Zhang· 3 shared H. Liu· 3 shared Q. Zhang· 3 shared Z. Chen· 3 shared G. Downey· 2 shared K. Aviszus· 2 shared L. Reynoso· 2 shared

Activity by Year

2017-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersImmunology

P. Marrack

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The Lambda variant of SARS-CoV-2 has a better chance than the Delta variant to escape vaccines

H. Liu, P. Wei, Q. Zhang, K. Aviszus, J. Linderberger, J. Yang, J. Liu, Z. Chen, H. Waheed, L. Reynoso, G. Downey, S. Frankel, J. Kappler, P. Marrack, G. Zhang

The paper compares vaccine efficacy against Delta and Lambda SARS-CoV-2 variants, finding Lambda has greater escape potential, with reduced antibody reactivity and therapeutic antibody binding.

bioRxiv · Aug 25, 2021 · PreprintImmunology

Predisposition to Proinsulin Misfolding as a Genetic Risk to Diet-Induced Diabetes

M. Alam, A. Arunagiri, L. Haataja, M. Torres, D. Larkin, J. Kappler, N. Jin, P. Arvan

This study shows that a proinsulin mutation increases susceptibility to diet-induced diabetes in mice, with severity linked to genetic dosage and beta-cell dysfunction.

bioRxiv · Jun 1, 2021Cell Biology

501Y.V2 and 501Y.V3 variants of SARS-CoV-2 lose binding to Bamlanivimab in vitro

H. Liu, P. Wei, Q. Zhang, Z. Chen, K. Aviszus, W. Downing, S. Peterson, L. Reynoso, G. Downey, S. Frankel, J. Kappler, P. Marrack, G. Zhang

The paper shows that the 501Y.V2 and 501Y.V3 SARS-CoV-2 variants have mutations that reduce binding to the antibody Bamlanivimab.

bioRxiv · Feb 16, 2021Biochemistry

JMJD6 Cleaves MePCE to Release P-TEFb

G. Zhang, S. Lee, H. Liu, R. Hill, X. Hong, X. Liu, F. Crawford, Q. Zhang, M. Kingsley, Z. Chen, A. Lengeling, K. Bernet, P. Marrack, J. Kappler, K. Hansen, , C.-Y. Li

The paper identifies JMJD6 as a protease that cleaves MePCE, releasing P-TEFb from the 7SK snRNP complex to enable Pol II-CTD phosphorylation.

bioRxiv · Aug 5, 2019 · PreprintBiochemistry

The somatically generated T cell receptor CDR3a contributes to the MHC allele specificity of the T cell receptor

P. Marrack, S. H. Krovi, D. Silberman, J. White, E. Kushnir, M. Nakayama, J. Crook, T. Danhorn, S. Leach, R. Anselment, J. Scott-Browne, L. Gapin, J. Kappler

The paper shows that the somatically generated CDR3a of T cell receptors influences MHC allele specificity during positive selection.

bioRxiv · Aug 15, 2017Immunology