Author

P. Marrack

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Immunology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Assay:proteomics· 4 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Organism:mouse· 2 Approach:statistical model· 2 Organism:virus· 2

Frequent Co-Authors

G. Zhang· 4 shared H. Liu· 4 shared J. Kappler· 4 shared Q. Zhang· 4 shared Z. Chen· 4 shared G. Downey· 3 shared K. Aviszus· 3 shared L. Reynoso· 3 shared

Activity by Year

2017-2021 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersBiochemistry

G. Zhang

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

The Lambda variant of SARS-CoV-2 has a better chance than the Delta variant to escape vaccines

H. Liu, P. Wei, Q. Zhang, K. Aviszus, J. Linderberger, J. Yang, J. Liu, Z. Chen, H. Waheed, L. Reynoso, G. Downey, S. Frankel, J. Kappler, P. Marrack, G. Zhang

The paper compares vaccine efficacy against Delta and Lambda SARS-CoV-2 variants, finding Lambda has greater escape potential, with reduced antibody reactivity and therapeutic antibody binding.

bioRxiv · Aug 25, 2021 · PreprintImmunology

501Y.V2 and 501Y.V3 variants of SARS-CoV-2 lose binding to Bamlanivimab in vitro

H. Liu, P. Wei, Q. Zhang, Z. Chen, K. Aviszus, W. Downing, S. Peterson, L. Reynoso, G. Downey, S. Frankel, J. Kappler, P. Marrack, G. Zhang

The paper shows that the 501Y.V2 and 501Y.V3 SARS-CoV-2 variants have mutations that reduce binding to the antibody Bamlanivimab.

bioRxiv · Feb 16, 2021Biochemistry

The basis of a more contagious 501Y.V1 variant of SARS-COV-2

G. Zhang, H. Liu, Q. Zhang, P. Wei, Z. Chen, K. Aviszus, J. Yang, W. Downing, S. Peterson, C. Jiang, B. Liang, L. Reynoso, G. Downey, S. Frankel, J. Kapper, P. Marrack

This paper investigates the increased transmissibility of the SARS-CoV-2 501Y.V1 variant due to the N501Y mutation in the Spike protein's RBD and its impact on ACE2 binding and vaccine efficacy.

bioRxiv · Feb 2, 2021Biochemistry

Immune-based mutation classification enables neoantigen prioritization and immune feature discovery in cancer immunotherapy

P. Bai, Y. Li, Q. Zhou, J. Xia, P.-C. Wei, H. Deng, M. Wu, S. K. Chan, J. W. Kappler, Y. Zhou, E. Tran, P. Marrack, L. Yin

The paper classifies neoantigens based on immune interactions and improves their prioritization for cancer immunotherapy.

bioRxiv · Jan 27, 2021Cancer Biology

Tolerance induction in memory CD4 T cells is partial and reversible

J. I. Gray, S. Al Khabouri, F. Morton, E. Clambey, L. Gapin, J. L. Matsuda, J. W. Kappler, P. Marrack, P. Garside, T. D. Otto, M. K. MacLeod

This study shows that memory CD4 T cells can partially tolerate antigen re-exposure but can be reversed by adjuvant-containing reactivation.

bioRxiv · May 25, 2020Immunology

JMJD6 Cleaves MePCE to Release P-TEFb

G. Zhang, S. Lee, H. Liu, R. Hill, X. Hong, X. Liu, F. Crawford, Q. Zhang, M. Kingsley, Z. Chen, A. Lengeling, K. Bernet, P. Marrack, J. Kappler, K. Hansen, , C.-Y. Li

The paper identifies JMJD6 as a protease that cleaves MePCE, releasing P-TEFb from the 7SK snRNP complex to enable Pol II-CTD phosphorylation.

bioRxiv · Aug 5, 2019 · PreprintBiochemistry

The somatically generated T cell receptor CDR3a contributes to the MHC allele specificity of the T cell receptor

P. Marrack, S. H. Krovi, D. Silberman, J. White, E. Kushnir, M. Nakayama, J. Crook, T. Danhorn, S. Leach, R. Anselment, J. Scott-Browne, L. Gapin, J. Kappler

The paper shows that the somatically generated CDR3a of T cell receptors influences MHC allele specificity during positive selection.

bioRxiv · Aug 15, 2017Immunology