APC Mutation marks an aggressive subtype of BRAF mutant colorectal cancers
L. Fennell, A. Kane, C. Liu, D. Mckeone, W. Fernando, C. Su, C. Bond, S. Jamieson, T. Dumenil, A.-M. Patch, S. Kazakoff, J. Pearson, N. Waddell, B. Leggett, V. Whitehall
This study identifies APC mutations as a marker of aggressive BRAF mutant colorectal cancers, associated with poor prognosis and enhanced tumor growth in mouse models.
bioRxiv · Feb 16, 2020Cancer Biology